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Answers from the BJC Experts

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I have been taking Allegra D 12 hour for a couple of days. I usually take it about 9 or 10 in the morning. Would it be alright to take the Benadryl at 8-9 in the evening? That's just an hour to two before the 12 hours.

Taking a sedating antihistamine like Benadryl (diphenhydramine) after taking a long acting antihistamine like Allegra (fexofenadine) could be a problem if you have to be alert. If you are not going to be driving or doing anything that would require clear thinking, or if you are going directly to bed, there most likely would not be a problem. 

The Allegra D (fexofenadine and pseudoephedrine) has a decongestant. If you have high blood pressure or heart disease, please speak to your doctor before taking this as it could cause your blood pressure to go up or put a stress on your heart.

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