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Answers from the BJC Experts

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Can I take acetaminophen with Xarelto? Looking for a cold medicine.

There are no direct drug interactions between acetaminophen (Tylenol) and Xarelto (rivaroxaban).  They may be taken together if needed.  Limit the acetaminophen to not more than 4000mg per day  (3200mg-J&J).  Take the Xarelto exactly as prescribed by your physician and report any unusual bleeding problems.  

Do not take any aspirin or NSAID's (like Motrin, Advil, Aleve) without consulting your physician first.  Using these drugs together may make you bruise or bleed more easily. This interaction can be serious for some people.

Many cold medications include aspirin or ibuprofen.  Please read the labels.  Generally speaking, the most common antihistamines and decongestants may be taken with the Xarelto.

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