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Answers from the BJC Experts

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I take metoprolol, pantoprazole and furosemide. Can I take metformin?

The metformin (Glucophage) can have minor interactions with diuretics and beta blockers. Since you are currently taking the metoprolol (Toprol, Lopressor) and furosemide (Lasix) and hopefully stabilized in the therapeutic ranges, as long as you have your blood pressure tested frequently, there most likely won’t be any problems. Beta-blockers can hide the symptoms of low blood sugar. Beta-blockers can also increase the blood sugar.

Your doctor has decided that taking these drugs together may benefit you. If you use a blood sugar monitoring device at home, check your blood sugar regularly. You should also learn how to recognize the signs of low blood sugar. Furosemide can slightly change the level of metformin in the blood, and vice versa. Also, furosemide may decrease the actions of metformin and increase blood sugar.

Although an interaction is possible, these drugs are often used together. If you use a blood sugar monitoring device at home, check your blood sugar regularly while taking metformin. If you notice an increase in your blood pressure or new or increased swelling of your legs or ankles while taking furosemide, tell your health care provider. The pantoprazole (Protonix) and metformin have no direct drug interactions between them.

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