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I have been taking Effexor xr 150mg, Ziac 2.5/6.25, and also pramipexole .25 mg. each of these is a qd dose. I have concerns that these drugs should not all be taken together as it seems they cause symptoms/side effects?

The pramipexole (Mirapex) does not directly interact with either the Effexor or Ziac. Although an interaction is possible, Effexor (venlafaxine) and diuretics, like hydrochlorothiazide (HCTZ) are often used together. Ziac (bisoprolol w/HCTZ) has hydrochlorothiazide.

Taking these medicines together may increase the chance of losing sodium from the bloodstream. Contact your prescriber if you experience side effects such as muscle weakness, nausea, vomiting, headache, confusion, fatigue, or any other unusual effects while taking these medicines together.

Both the Effexor and pramipexole list confusion, drowsiness and dizziness as side effects. Generally these pass as your body gets used to the medications. Be careful if you must be alert. If you notice problems, please contact the physician that prescribed these for you.

Make sure that all of your health care providers have a current list of your medications and conditions.

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