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Can I take Benadryl, Prednisone, and Motrin IB 200mg?

The Benadryl (diphenhydramine) does not have any direct drug interactions with either prednisone (Deltasone) or Motrin IB (ibuprofen). The Benadryl can cause drowsiness, be careful if you must be alert.

The other two are both anti-inflammatory medications, the prednisone a steroid, the Motrin an NSAID. Although an interaction is possible, these drugs may be used together for short periods of time. Side effects from NSAIDs, such as stomach upset, nausea, or heartburn may get worse if you also take prednisone, especially if taken together for prolonged periods of time.

I would recommend not taking these two at the same time at least. Normally the prednisone is given with breakfast, in the morning. Take each of these with food or milk.

Follow the instructions your doctor gave for the prednisone. Take the Benadryl and Motrin only as needed.

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