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Answers from the BJC Experts

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Can Armour Thyroid, levothyroxine, metformin, phentermine, Cymbalta, and crestor be taken together?

The major problem drug of this list is the phentermine (Adipex). This interacts with all the others except the Crestor (rosuvastatin). The Crestor does not interact with any of these on your list.

You have two thyroid drugs included here. The Armour Thyroid is a desiccated natural thyroid product and the levothyroxine (Synthroid) is a synthetic thyroid hormone. Normally a patient would not take both. I would suggest speaking with your physician about this duplication.

The phentermine interacts with the Cymbalta (duloxetine) and both thyroid products in a way that can increase the risk of confusion, increased blood pressure or heart rate, loss of coordination, restlessness, sweating, tremor, vomiting, or other serious side effects. Do not take Cymbalta and phentermine together without talking to your health care provider. The problems with the thyroid products and phentermine are similar.

The issue with the metformin (Glucophage) and phentermine is that if taken together may lead to a change in your blood sugar. If you use a blood sugar monitoring device at home, check your blood sugar regularly while taking these medicines together. The metformin may also interact with the thyroid drugs but these drugs are often used together safely.

Proper function of the thyroid gland is important in the regulation of blood sugar. As your low thyroid condition corrects with the use of thyroid hormones, changes in blood sugar may occur. If you use a blood sugar monitoring system, monitor your blood sugar periodically. Always be sure that your health care providers have a current list of all your medications. Have your pharmacist always check for drug interactions when getting your prescriptions filled.

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