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Answers from the BJC Experts

Ask the BJC Expert allows you to get the answers you need about a variety of health, medicine and exercise issues to help you live a more healthy life.

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Can I take Bactrim with Advil Cold and Sinus? I have a sinus infection.

There are no direct drug interactions between Bactrim (SMX-TMP, Septra) and Advil Cold and Sinus (ibuprofen, pseudoephedrine). They may be taken together if needed. Drink plenty of water with the Bactrim. It is a sulfa type antibiotic which needs to be flushed through the kidneys. If you have high blood pressure or heart disease, please speak to your health care provider before taking any oral decongestant like pseudoephedrine (Sudafed). Take the antibiotic until finished.

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