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Answers from the BJC Experts

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Can I take a cold medication like Tylenol Cold while taking nifedipine and HCTZ?

There are no direct drug interactions between Tylenol Cold (acetaminophen,chlorpheniramine,dextromethorphan,pseudoephedrine), nifedipine (Procardia) and HCTZ (hydrochlorothiazide). Use the Tylenol Cold only as needed. Limit the daily amount of acetaminophen (Tylenol) to 4000mg or less.

There are several formulations of Tylenol Cold. If you are taking the nifedipine or HCTZ for high blood pressure, and the Tylenol Cold product has a decongestant (pseudoephedrine or phenylephrine), please contact your physician. Oral decongestants can cause some issues with people who have blood pressure or some forms of heart disease.

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